EXPERIMENTAL EVALUATION OF TISSUES’ CHANGES OF DOUBLE LAYER SMALL BOWEL ANASTOMOSIS AT VARIOUS AGE 

Markos'yan Sergey Anatol'evich, Doctor of medical sciences, professor, sub-department of faculty surgery, National Research Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), markosyansa@mail.ru
Vlasov Aleksey Petrovich, Doctor of medical sciences, professor, head of the sub-department of faculty surgery, National Research Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia),vap.61@yandex.ru

617-089:616.341

10.21685/2072-3032-2018-1-2

Background. The problem related to the age specific regeneration features of the intestinal anastomosis is actual until present days. The research goal is to study morphofunctional changes of animals’ double layer small bowel anastomosis at various ages.
Materials and methods. Experimental studies were conducted on 35 impuberal and puberal dogs. The parameters characterizing the state of regional bloodstream, metabolism in the tissues of intestinal anastomosis, functional anastomosis competence were researched. A macroscopic evaluation of postoperative changes in the abdominal cavity was performed. The formation of database and statistical calculations were carried out using Microsoft Excel, ANO-VA for Windows applications.
Results. Experimental studies have established that in the tissues of double layer small bowel anastomosis, a significant disorder of the regional circulation and a metabolic disorder were determined. The predominant emergence of pronounced irreversible edema in the region of anastomosis without nonviable tissues sequestration into the intestinal lumen in the first day after the operation caused a low physical impermeability of the anastomoses, a slowing their regeneration and the development of frequent postoperative complications in the form of anastomosis incompetence, especially in immature animals.
Conclusions. The decisive factor in the pathogenesis of the frequent disruption of the regenerative process in the tissues of the double-row anastomosis is decompensated metabolic disorders and the development of irreversible edema without the exudate sequestration into the intestinal lumen. Larger morphofunctional disturbances in the tissue structures of intestinal anastomosis in immature animals cause the emergence of a comparatively larger number of postoperative complications in the form of anastomosis incompetence and peritonitis accompanied with high postoperative lethality.

impuberal animals, puberal animals, double layer small bowel anastomosis

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